Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

TGF-β–activated kinase 1 (TAK1) is a MAP3K family member that activates NF-κB and JNK via Toll-like receptors and the receptors for IL-1, TNF-α, and TGF-β. Because the TAK1 downstream molecules NF-κB and JNK have opposite effects on cell death and carcinogenesis, the role of TAK1 in the liver is unp...

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Bibliographic Details
Main Authors: Inokuchi, Sayaka, Aoyama, Tomonori, Miura, Kouichi, Österreicher, Christoph H., Kodama, Yuzo, Miyai, Katsumi, Akira, Shizuo, Brenner, David A., Seki, Ekihiro
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818947/
https://ncbi.nlm.nih.gov/pubmed/20080763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909781107
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