Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

Complement component C1, the complex that initiates the classical pathway of complement activation, is a 790-kDa assembly formed from the target-recognition subcomponent C1q and the modular proteases C1r and C1s. The proteases are elongated tetramers that become more compact when they bind to the co...

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Bibliografiset tiedot
Päätekijät: Venkatraman Girija, Umakhanth, Gingras, Alexandre R., Marshall, Jamie E., Panchal, Roshni, Sheikh, Md. Arif, Harper, James A. J., Gál, Péter, Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E., Wallis, Russell
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2013
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752233/
https://ncbi.nlm.nih.gov/pubmed/23922389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311113110
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