Structure of the C1r–C1s interaction of the C1 complex of complement activation

The multiprotein complex C1 initiates the classical pathway of complement activation on binding to antibody–antigen complexes, pathogen surfaces, apoptotic cells, and polyanionic structures. It is formed from the recognition subcomponent C1q and a tetramer of proteases C1r(2)C1s(2) as a Ca(2+)-depen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Almitairi, Jamal O. M., Venkatraman Girija, Umakhanth, Furze, Christopher M., Simpson-Gray, Xanthe, Badakshi, Farah, Marshall, Jamie E., Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E., Wallis, Russell
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789954/
https://ncbi.nlm.nih.gov/pubmed/29311313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718709115
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