Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

Complement component C1, the complex that initiates the classical pathway of complement activation, is a 790-kDa assembly formed from the target-recognition subcomponent C1q and the modular proteases C1r and C1s. The proteases are elongated tetramers that become more compact when they bind to the co...

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Detalhes bibliográficos
Main Authors: Venkatraman Girija, Umakhanth, Gingras, Alexandre R., Marshall, Jamie E., Panchal, Roshni, Sheikh, Md. Arif, Harper, James A. J., Gál, Péter, Schwaeble, Wilhelm J., Mitchell, Daniel A., Moody, Peter C. E., Wallis, Russell
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752233/
https://ncbi.nlm.nih.gov/pubmed/23922389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311113110
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