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Human PIEZO1: Removing Inactivation

PIEZO1 is an inactivating eukaryotic cation-selective mechanosensitive ion channel. Two sites have been located in the channel that when individually mutated lead to xerocytotic anemia by slowing inactivation. By introducing mutations at two sites, one associated with xerocytosis and the other artif...

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Autori principali: Bae, Chilman, Gottlieb, Philip A., Sachs, Frederick
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752115/
https://ncbi.nlm.nih.gov/pubmed/23972840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.019
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