Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson’s disease, causes behavioral alterations but not neurodegeneration in mice

BACKGROUND: In autosomal recessive early-onset Parkinsonism (PARK2), the pathogenetic process from the loss of function of a ubiquitin ligase parkin to the death of dopamine neurons remains unclear. A dominant hypothesis attributes the neurotoxicity to accumulated substrates that are exempt from par...

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Hlavní autoři: Ageta-Ishihara, Natsumi, Yamakado, Hodaka, Morita, Takao, Hattori, Satoko, Takao, Keizo, Miyakawa, Tsuyoshi, Takahashi, Ryosuke, Kinoshita, Makoto
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751304/
https://ncbi.nlm.nih.gov/pubmed/23938054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-35
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