Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson’s disease, causes behavioral alterations but not neurodegeneration in mice

BACKGROUND: In autosomal recessive early-onset Parkinsonism (PARK2), the pathogenetic process from the loss of function of a ubiquitin ligase parkin to the death of dopamine neurons remains unclear. A dominant hypothesis attributes the neurotoxicity to accumulated substrates that are exempt from par...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Ageta-Ishihara, Natsumi, Yamakado, Hodaka, Morita, Takao, Hattori, Satoko, Takao, Keizo, Miyakawa, Tsuyoshi, Takahashi, Ryosuke, Kinoshita, Makoto
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751304/
https://ncbi.nlm.nih.gov/pubmed/23938054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-35
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares