The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

Understanding the mechanism underlying the regulation of the androgen receptor (AR), a central player in the development of castration-resistant prostate cancer (CRPC), holds promise for overcoming the challenge of treating CRPC. We demonstrate that the ubiquitin ligase Siah2 targets a select pool o...

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Bibliographic Details
Main Authors: Qi, Jianfei, Tripathi, Manisha, Mishra, Rajeev, Sahgal, Natasha, Fazil, Ladan, Ettinger, Susan, Placzek, William J., Claps, Giuseppina, Chung, Leland W.K., Bowtell, David, Gleave, Martin, Bhowmick, Neil, Ronai, Ze'ev A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750989/
https://ncbi.nlm.nih.gov/pubmed/23518348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.02.016
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