TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1(+)CD11b(+) Neutrophils

Stringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical during innate immune responses. TGF-β activated kinase-1 (TAK1) is essential for NF-κB activation in T and B cells but has precisely the opposite activity in myeloid cells. Specific deletion of TAK1 (Map3k7(...

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Hauptverfasser: Ajibade, Adebusola Alagbala, Wang, Qinfu, Cui, Jun, Zou, Jia, Xia, Xiaojun, Wang, Mingjun, Tong, Yanzheng, Hui, Wei, Liu, Dou, Su, Bing, Wang, Helen Y., Wang, Rong-Fu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750978/
https://ncbi.nlm.nih.gov/pubmed/22226633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.010
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