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TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1(+)CD11b(+) Neutrophils
Stringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical during innate immune responses. TGF-β activated kinase-1 (TAK1) is essential for NF-κB activation in T and B cells but has precisely the opposite activity in myeloid cells. Specific deletion of TAK1 (Map3k7(...
में बचाया:
मुख्य लेखकों: | , , , , , , , , , , , |
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स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
2012
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3750978/ https://ncbi.nlm.nih.gov/pubmed/22226633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.010 |
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