Crosslinking and mass spectrometry suggest that the isolated NTD domain dimer of Moloney murine leukemia virus integrase adopts a parallel arrangement in solution

BACKGROUND: Retroviral integrases (INs) catalyze the integration of viral DNA in the chromosomal DNA of the infected cell. This reaction requires the multimerization of IN to coordinate a nucleophilic attack of the 3’ ends of viral DNA at two staggered phosphodiester bonds on the recipient DNA. Seve...

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Detalhes bibliográficos
Main Authors: Henriquez, Daniel R, Zhao, Caifeng, Zheng, Haiyan, Arbildua, José J, Acevedo, Mónica L, Roth, Monica J, Leon, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750625/
https://ncbi.nlm.nih.gov/pubmed/23844665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-13-14
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