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Synonymous site conservation in the HIV-1 genome

BACKGROUND: Synonymous or silent mutations are usually thought to evolve neutrally. However, accumulating recent evidence has demonstrated that silent mutations may destabilize RNA structures or disrupt cis regulatory motifs superimposed on coding sequences. Such observations suggest the existence o...

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Main Authors: Mayrose, Itay, Stern, Adi, Burdelova, Ela O, Sabo, Yosef, Laham-Karam, Nihay, Zamostiano, Rachel, Bacharach, Eran, Pupko, Tal
格式: Artigo
語言:Inglês
出版: BioMed Central 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750384/
https://ncbi.nlm.nih.gov/pubmed/23914950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-13-164
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