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Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes
A hallmark of the human immunodeficiency virus 1 (HIV-1) is its rapid rate of evolution within and among its various subtypes. Two complementary hypotheses are suggested to explain the sequence variability among HIV-1 subtypes. The first suggests that the functional constraints at each site remain t...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566816/ https://ncbi.nlm.nih.gov/pubmed/18989394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000214 |
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