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Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes

A hallmark of the human immunodeficiency virus 1 (HIV-1) is its rapid rate of evolution within and among its various subtypes. Two complementary hypotheses are suggested to explain the sequence variability among HIV-1 subtypes. The first suggests that the functional constraints at each site remain t...

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Detalhes bibliográficos
Main Authors: Penn, Osnat, Stern, Adi, Rubinstein, Nimrod D., Dutheil, Julien, Bacharach, Eran, Galtier, Nicolas, Pupko, Tal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566816/
https://ncbi.nlm.nih.gov/pubmed/18989394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000214
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