Creation of a Merkel cell polyomavirus small T antigen-expressing murine tumor model and a DNA vaccine targeting small T antigen

BACKGROUND: Merkel cell polyomavirus (MCPyV) is a DNA virus expressing transcripts similar to the large T (LT) and small T (ST) transcripts of SV40, which has been implicated in the pathogenesis of Merkel cell carcinoma (MCC), a rare and highly aggressive neuroendocrine skin cancer. MCPyV LT antigen...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gomez, Bianca, He, Liangmei, Tsai, Ya Chea, Wu, T-C, Viscidi, Raphael P, Hung, Chien-Fu
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750327/
https://ncbi.nlm.nih.gov/pubmed/23856459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-3-29
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