The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily: A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE

Glutathione transferases (GSTs) are protection enzymes capable of conjugating glutathione (GSH) to toxic compounds. During evolution an important catalytic cysteine residue involved in GSH activation was replaced by serine or, more recently, by tyrosine. The utility of these replacements represents...

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Główni autorzy: Bocedi, Alessio, Fabrini, Raffaele, Farrotti, Andrea, Stella, Lorenzo, Ketterman, Albert J., Pedersen, Jens Z., Allocati, Nerino, Lau, Peter C. K., Grosse, Stephan, Eltis, Lindsay D., Ruzzini, Antonio, Edwards, Thomas E., Morici, Laura, Del Grosso, Erica, Guidoni, Leonardo, Bovi, Daniele, Lo Bello, Mario, Federici, Giorgio, Parker, Michael W., Board, Philip G., Ricci, Giorgio
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2013
Hasła przedmiotowe:
Enzymology
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750189/
https://ncbi.nlm.nih.gov/pubmed/23828197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476135
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