The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily: A PROPOSAL FOR AN EVOLUTIONARY DRIVING FORCE

Glutathione transferases (GSTs) are protection enzymes capable of conjugating glutathione (GSH) to toxic compounds. During evolution an important catalytic cysteine residue involved in GSH activation was replaced by serine or, more recently, by tyrosine. The utility of these replacements represents...

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Bibliografische gegevens
Hoofdauteurs: Bocedi, Alessio, Fabrini, Raffaele, Farrotti, Andrea, Stella, Lorenzo, Ketterman, Albert J., Pedersen, Jens Z., Allocati, Nerino, Lau, Peter C. K., Grosse, Stephan, Eltis, Lindsay D., Ruzzini, Antonio, Edwards, Thomas E., Morici, Laura, Del Grosso, Erica, Guidoni, Leonardo, Bovi, Daniele, Lo Bello, Mario, Federici, Giorgio, Parker, Michael W., Board, Philip G., Ricci, Giorgio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750189/
https://ncbi.nlm.nih.gov/pubmed/23828197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476135
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