Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3β in Pancreatic β-Cells

In pancreatic β-cells, glucose induces the binding of the transcription factor pancreatic duodenal homeobox-1 (PDX-1) to the insulin gene promoter to activate insulin gene transcription. At low glucose levels, glycogen synthase kinase 3β (GSK3β) is known to phosphorylate PDX-1 on C-terminal serine r...

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Autores principales: Semache, Meriem, Zarrouki, Bader, Fontés, Ghislaine, Fogarty, Sarah, Kikani, Chintan, Chawki, Mohammad B., Rutter, Jared, Poitout, Vincent
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750177/
https://ncbi.nlm.nih.gov/pubmed/23853095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495945
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