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Peptide Modulation of Class I Major Histocompatibility Complex Protein Molecular Flexibility and the Implications for Immune Recognition

T cells use the αβ T cell receptor (TCR) to recognize antigenic peptides presented by class I major histocompatibility complex proteins (pMHCs) on the surfaces of antigen-presenting cells. Flexibility in both TCRs and peptides plays an important role in antigen recognition and discrimination. Less c...

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Autors principals: Hawse, William F., Gloor, Brian E., Ayres, Cory M., Kho, Kevin, Nuter, Elizabeth, Baker, Brian M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750139/
https://ncbi.nlm.nih.gov/pubmed/23836912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.490664
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