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Solution Phase Synthesis of a Diverse Library of Highly Substituted Isoxazoles

The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, ace...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Waldo, Jesse P., Mehta, Saurabh, Neuenswander, Benjamin, Lushington, Gerald H., Larock, Richard C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750120/
https://ncbi.nlm.nih.gov/pubmed/18671435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc800055x
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