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Reversal of Substrate Specificity of CMP N-glycosidase to dCMP,

MilB is a CMP hydrolase involved in the early steps of biosynthesis of the antifungal compound mildiomycin. An enzyme from the bacimethrin biosynthetic pathway, BcmB, is closely related in both sequence and function to MilB. These two enzymes belong to the nucleoside 2′-deoxyribosyltransferase (NDT)...

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Bibliografske podrobnosti
Main Authors: Sikowitz, Megan D., Cooper, Lisa, Begley, Tadhg P., Kaminski, Pierre Alexandre, Ealick, Steven E.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750073/
https://ncbi.nlm.nih.gov/pubmed/23659472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400316p
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