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Reversal of Substrate Specificity of CMP N-glycosidase to dCMP,

MilB is a CMP hydrolase involved in the early steps of biosynthesis of the antifungal compound mildiomycin. An enzyme from the bacimethrin biosynthetic pathway, BcmB, is closely related in both sequence and function to MilB. These two enzymes belong to the nucleoside 2′-deoxyribosyltransferase (NDT)...

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Hlavní autoři: Sikowitz, Megan D., Cooper, Lisa, Begley, Tadhg P., Kaminski, Pierre Alexandre, Ealick, Steven E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750073/
https://ncbi.nlm.nih.gov/pubmed/23659472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400316p
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