TRIM5 alpha Drives SIVsmm Evolution in Rhesus Macaques

The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of the TRIM5α B30.2/SPRY domain impacted the level of SIVsmm viremia in rhesus macaques. Viremia in macaques homozygous for the non-restrictive...

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Main Authors: Wu, Fan, Kirmaier, Andrea, Goeken, Robert, Ourmanov, Ilnour, Hall, Laura, Morgan, Jennifer S., Matsuda, Kenta, Buckler-White, Alicia, Tomioka, Keiko, Plishka, Ronald, Whitted, Sonya, Johnson, Welkin, Hirsch, Vanessa M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749954/
https://ncbi.nlm.nih.gov/pubmed/23990789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003577
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