Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network

Molecular mechanisms of the mammalian circadian clock have been studied primarily by genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to monitor Per2 gene expression in tissues and cells from clock mutant mice. We discovered that Per1 and Cry1 are required for sust...

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Detalhes bibliográficos
Main Authors: Liu, Andrew C., Welsh, David K., Ko, Caroline H., Tran, Hien G., Zhang, Eric E., Priest, Aaron A., Buhr, Ethan D., Singer, Oded, Meeker, Kirsten, Verma, Inder M., Doyle III, Francis J., Takahashi, Joseph S., Kay, Steve A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749832/
https://ncbi.nlm.nih.gov/pubmed/17482552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.02.047
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