Development of an imaging-guided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: first clinical results

BACKGROUND: Radiolabelled antibody targeting of cancer is limited by slow blood clearance. Pretargeting with a non-radiolabelled bispecific monoclonal antibody (bsMAb) followed by a rapidly clearing radiolabelled hapten peptide improves tumour localisation. The primary goals of this first pretargeti...

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Detalhes bibliográficos
Main Authors: Schoffelen, R, Boerman, O C, Goldenberg, D M, Sharkey, R M, van Herpen, C M L, Franssen, G M, McBride, W J, Chang, C-H, Rossi, E A, van der Graaf, W T A, Oyen, W J G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749562/
https://ncbi.nlm.nih.gov/pubmed/23860529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.376
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