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Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress

BACKGROUND: Refractoriness of glioblastoma multiforme (GBM) largely depends on its radioresistance. We investigated the radiosensitizing effects of celecoxib on GBM cell lines under both normoxic and hypoxic conditions. METHODS: Two human GBM cell lines, U87MG and U251MG, and a mouse GBM cell line,...

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Bibliografiske detaljer
Main Authors: Suzuki, Kenshi, Gerelchuluun, Ariungerel, Hong, Zhengshan, Sun, Lue, Zenkoh, Junko, Moritake, Takashi, Tsuboi, Koji
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748914/
https://ncbi.nlm.nih.gov/pubmed/23658321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not062
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