Toll-like Receptor 4 Deficiency Decreases Atherosclerosis but Does Not Protect against Inflammation in Obese LDL Receptor-Deficient Mice

OBJECTIVE: Obesity is associated with insulin resistance, chronic low-grade inflammation and atherosclerosis. Toll-like receptor 4 (TLR4) participates in the cross-talk between inflammation and insulin resistance, being activated by both lipopolysaccharide and saturated fatty acids. This study was u...

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Huvudupphovsmän: Ding, Yilei, Subramanian, Savitha, Montes, Vince N., Goodspeed, Leela, Wang, Shari, Han, Chang Yeop, Teresa, Antonio Sta., Kim, Jinkyu, O’Brien, Kevin D., Chait, Alan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748807/
https://ncbi.nlm.nih.gov/pubmed/22580897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.249847
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