APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice

ApoE, ApoE receptors and APP cooperate in the pathogenesis of Alzheimer’s disease. Intriguingly, the ApoE receptor LRP4 and APP are also required for normal formation and function of the neuromuscular junction (NMJ). In this study, we show that APP interacts with LRP4, an obligate co-receptor for mu...

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Detalhes bibliográficos
Main Authors: Choi, Hong Y, Liu, Yun, Tennert, Christian, Sugiura, Yoshie, Karakatsani, Andromachi, Kröger, Stephan, Johnson, Eric B, Hammer, Robert E, Lin, Weichun, Herz, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748711/
https://ncbi.nlm.nih.gov/pubmed/23986861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00220
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