A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

TYK2 is a JAK family protein tyrosine kinase activated in response to multiple cytokines, including type I IFNs, IL-6, IL-10, IL-12, and IL-23. Extensive studies of mice that lack TYK2 expression indicate that the IFN-α, IL-12, and IL-23 pathways, but not the IL-6 or IL-10 pathways, are compromised....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Sohn, Sue J., Barrett, Kathy, Van Abbema, Anne, Chang, Christine, Kohli, Pawan Bir, Kanda, Hidenobu, Smith, Janice, Lai, Yingjie, Zhou, Aihe, Zhang, Birong, Yang, Wenqian, Williams, Karen, Macleod, Calum, Hurley, Christopher A., Kulagowski, Janusz J., Lewin-Koh, Nicholas, Dengler, Hart S., Johnson, Adam R., Ghilardi, Nico, Zak, Mark, Liang, Jun, Blair, Wade S., Magnuson, Steven, Wu, Lawren C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: AAI 2013
विषय:
Clinical and Human Immunology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748334/
https://ncbi.nlm.nih.gov/pubmed/23894201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202859
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