Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition thought to reflect a failure of the enteral immune system to adequately regulate itself. Inflammatory stress drives up-regulation of heat-shock proteins (HSP) including the pro-inflammatory chaperone, HSP90. This protein sequesters...

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Detalhes bibliográficos
Main Authors: Collins, Colm B., Aherne, Carol M., Yeckes, Alyson, Pound, Kayla, Eltzschig, Holger K., Jedlicka, Paul, de Zoeten, Edwin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748235/
https://ncbi.nlm.nih.gov/pubmed/23321985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.134
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