Increased Anandamide Uptake by Sensory Neurons Contributes to Hyperalgesia in a Model of Cancer Pain

Opioids do not effectively manage pain in many patients with advanced cancer. Because anandamide (AEA) activation of cannabinoid type-1 receptors (CB1R) on nociceptors reduces nociception, manipulation of AEA metabolism in the periphery may be an effective alternative or adjuvant therapy in the mana...

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Bibliografiska uppgifter
Huvudupphovsmän: Khasabova, Iryna A., Holman, Michelle, Morse, Tim, Burlakova, Natalya, Coicou, Lia, Harding-Rose, Catherine, Simone, Don A., Seybold, Virginia S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748184/
https://ncbi.nlm.nih.gov/pubmed/23644187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.04.018
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