The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist

Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the controversy regarding the pharmacological action...

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Autors principals: Erickson, Catherine E., Gul, Rukhsana, Blessing, Christopher P., Nguyen, Jenny, Liu, Tammy, Pulakat, Lakshmi, Bastepe, Murat, Jackson, Edwin K., Andresen, Bradley T.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748024/
https://ncbi.nlm.nih.gov/pubmed/23977191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071980
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