Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice

AMP-activated protein kinase (AMPK) is an energy sensor of metabolism that is an attractive therapeutic target for type 2 diabetes mellitus and metabolic syndrome. Using a homogeneous scintillation proximity assay (SPA), we identified a new small-molecule AMPK activator, ZLN024, which allosterically...

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Hauptverfasser: Zhang, Li-Na, Xu, Lei, Zhou, Hua-Yong, Wu, Ling-Yan, Li, Yuan-Yuan, Pang, Tao, Xia, Chun-Mei, Qiu, Bei-Ying, Gu, Min, Dong, Tian-Cheng, Li, Jing-Ya, Shen, Jing-Kang, Li, Jia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748009/
https://ncbi.nlm.nih.gov/pubmed/23977216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072092
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