Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) has been shown to influence energy metabolism. Hence, we explored a strategy to target PGC-1α expression to treat metabolic syndromes. We developed a high-throughput screening assay that uses the human PGC-1α promoter to drive expr...

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Detalhes bibliográficos
Main Authors: Zhang, Li-Na, Zhou, Hua-Yong, Fu, Yan-Yun, Li, Yuan-Yuan, Wu, Fang, Gu, Min, Wu, Ling-Yan, Xia, Chun-Mei, Dong, Tian-Cheng, Li, Jing-Ya, Shen, Jing-Kang, Li, Jia
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609556/
https://ncbi.nlm.nih.gov/pubmed/23250358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0703
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