Nonvolatile salt-free stabilizer for the quantification of polar imipenem and cilastatin in human plasma using hydrophilic interaction chromatography/quadrupole mass spectrometry with contamination sensitive off-axis electrospray

A hydrophilic interaction chromatography/mass spectrometry (HILIC-MS)-based assay for imipenem (IMP) and cilastatin (CIL) was recently reported. This orthogonal electrospray ion source-based (ORS) assay utilized nonvolatile salt (unremovable) to stabilize IMI in plasma. Unfortunately, this method wa...

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Main Authors: Hu, Zhe-Yi, Boucher, Bradley A., Laizure, S. Casey, Herring, Vanessa L., Parker, Robert B., Hickerson, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747842/
https://ncbi.nlm.nih.gov/pubmed/23893642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jms.3240
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