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Atg18 phosphoregulation controls organellar dynamics by modulating its phosphoinositide-binding activity

The PROPPIN family member Atg18 is a phosphoinositide-binding protein that is composed of a seven β-propeller motif and is part of the conserved autophagy machinery. Here, we report that the Atg18 phosphorylation in the loops in the propellar structure of blade 6 and blade 7 decreases its binding af...

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Detalhes bibliográficos
Main Authors: Tamura, Naoki, Oku, Masahide, Ito, Moemi, Noda, Nobuo N., Inagaki, Fuyuhiko, Sakai, Yasuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747300/
https://ncbi.nlm.nih.gov/pubmed/23940117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302067
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