Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18

Autophagy is an intracellular degradation system by which cytoplasmic materials are enclosed by an autophagosome and delivered to a lysosome/vacuole. Atg18 plays a critical role in autophagosome formation as a complex with Atg2 and phosphatidylinositol 3-phosphate (PtdIns(3)P). However, little is kn...

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Bibliografiske detaljer
Main Authors: Watanabe, Yasunori, Kobayashi, Takafumi, Yamamoto, Hayashi, Hoshida, Hisashi, Akada, Rinji, Inagaki, Fuyuhiko, Ohsumi, Yoshinori, Noda, Nobuo N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442503/
https://ncbi.nlm.nih.gov/pubmed/22851171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397570
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