Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

The V-type nerve agents (VX and VR) are among the most toxic substances known. The high toxicity and environmental persistence of VX makes the development of novel decontamination methods particularly important. The enzyme phosphotriesterase (PTE) is capable of hydrolyzing VX but with an enzymatic e...

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Bibliografiske detaljer
Main Authors: Bigley, Andrew N., Xu, Chengfu, Henderson, Terry J., Harvey, Steven P., Raushel, Frank M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747228/
https://ncbi.nlm.nih.gov/pubmed/23789980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja402832z
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