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A Mathematical Model of Cancer Stem Cell Driven Tumor Initiation: Implications of Niche Size and Loss of Homeostatic Regulatory Mechanisms

Hierarchical organized tissue structures, with stem cell driven cell differentiation, are critical to the homeostatic maintenance of most tissues, and this underlying cellular architecture is potentially a critical player in the development of a many cancers. Here, we develop a mathematical model of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gentry, Sara N., Jackson, Trachette L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747196/
https://ncbi.nlm.nih.gov/pubmed/23990931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071128
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