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A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment

Targeting key regulators of the cancer stem cell phenotype to overcome their critical influence on tumor growth is a promising new strategy for cancer treatment. Here we present a modeling framework that operates at both the cellular and molecular levels, for investigating IL-6 mediated, cancer stem...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Nazari, Fereshteh, Pearson, Alexander T., Nör, Jacques Eduardo, Jackson, Trachette L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792033/
https://ncbi.nlm.nih.gov/pubmed/29351275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005920
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