HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

HIV persists in a reservoir of latently infected CD4(+) T cells in individuals treated with highly active antiretroviral therapy (HAART). Here we identify central memory (T(CM)) and transitional memory (T(TM)) CD4(+) T cells as the major cellular reservoirs for HIV and find that viral persistence is...

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Detalhes bibliográficos
Main Authors: Chomont, Nicolas, El-Far, Mohamed, Ancuta, Petronela, Trautmann, Lydie, Procopio, Francesco A, Yassine-Diab, Bader, Boucher, Geneviève, Boulassel, Mohamed-Rachid, Ghattas, Georges, Brenchley, Jason M, Schacker, Timothy W, Hill, Brenna J, Douek, Daniel C, Routy, Jean-Pierre, Haddad, Elias K, Sékaly, Rafick-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859814/
https://ncbi.nlm.nih.gov/pubmed/19543283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1972
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