Deletion of Glutathione Peroxidase-2 Inhibits Azoxymethane-Induced Colon Cancer Development

The selenoprotein glutathione peroxidase-2 (GPx2) appears to have a dual role in carcinogenesis. While it protected mice from colon cancer in a model of inflammation-triggered carcinogenesis (azoxymethane and dextran sodium sulfate treatment), it promoted growth of xenografted tumor cells. Therefore...

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Autors principals: Müller, Mike F., Florian, Simone, Pommer, Stefanie, Osterhoff, Martin, Esworthy, R. Steven, Chu, Fong-Fong, Brigelius-Flohé, Regina, Kipp, Anna P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747154/
https://ncbi.nlm.nih.gov/pubmed/23977205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072055
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