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Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply

Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of selenium might be mediated by specific selenoproteins, such as glutathione peroxidases (GPx). GPx-1 and -2 double knockout, but not single knockout mice, spontaneously develop ileoc...

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Detalhes bibliográficos
Main Authors: Krehl, Susanne, Loewinger, Maria, Florian, Simone, Kipp, Anna P., Banning, Antje, Wessjohann, Ludger A., Brauer, Martin N., Iori, Renato, Esworthy, Robert S., Chu, Fong-Fong, Brigelius-Flohé, Regina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291858/
https://ncbi.nlm.nih.gov/pubmed/22180572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr288
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