Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply

Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of selenium might be mediated by specific selenoproteins, such as glutathione peroxidases (GPx). GPx-1 and -2 double knockout, but not single knockout mice, spontaneously develop ileoc...

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Bibliographische Detailangaben
Hauptverfasser: Krehl, Susanne, Loewinger, Maria, Florian, Simone, Kipp, Anna P., Banning, Antje, Wessjohann, Ludger A., Brauer, Martin N., Iori, Renato, Esworthy, Robert S., Chu, Fong-Fong, Brigelius-Flohé, Regina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Inflammation, Microenvironment and Prevention
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291858/
https://ncbi.nlm.nih.gov/pubmed/22180572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr288
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