Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply

Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of selenium might be mediated by specific selenoproteins, such as glutathione peroxidases (GPx). GPx-1 and -2 double knockout, but not single knockout mice, spontaneously develop ileoc...

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Autores principales: Krehl, Susanne, Loewinger, Maria, Florian, Simone, Kipp, Anna P., Banning, Antje, Wessjohann, Ludger A., Brauer, Martin N., Iori, Renato, Esworthy, Robert S., Chu, Fong-Fong, Brigelius-Flohé, Regina
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Inflammation, Microenvironment and Prevention
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291858/
https://ncbi.nlm.nih.gov/pubmed/22180572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr288
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