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Structural basis of Vps33A recruitment to the human HOPS complex by Vps16
The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18 fam...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746937/ https://ncbi.nlm.nih.gov/pubmed/23901104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307074110 |
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