Structural basis of Vps33A recruitment to the human HOPS complex by Vps16

The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18 fam...

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Hlavní autoři: Graham, Stephen C., Wartosch, Lena, Gray, Sally R., Scourfield, Edward J., Deane, Janet E., Luzio, J. Paul, Owen, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746937/
https://ncbi.nlm.nih.gov/pubmed/23901104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307074110
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