Neuronal prostaglandin E(2) receptor subtype EP3 mediates antinociception during inflammation

The pain mediator prostaglandin E(2) (PGE(2)) sensitizes nociceptive pathways through EP2 and EP4 receptors, which are coupled to G(s) proteins and increase cAMP. However, PGE(2) also activates EP3 receptors, and the major signaling pathway of the EP3 receptor splice variants uses inhibition of cAMP...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Natura, Gabriel, Bär, Karl-Jürgen, Eitner, Annett, Boettger, Michael K., Richter, Frank, Hensellek, Susanne, Ebersberger, Andrea, Leuchtweis, Johannes, Maruyama, Takayuki, Hofmann, Gunther Olaf, Halbhuber, Karl-Jürgen, Schaible, Hans-Georg
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746931/
https://ncbi.nlm.nih.gov/pubmed/23904482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300820110
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker