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The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo

The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates stroke-induced pathology. In anesthetized rats we ap...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Richter, Frank, Eitner, Annett, Leuchtweis, Johannes, Bauer, Reinhard, Ebersberger, Andrea, Lehmenkühler, Alfred, Schaible, Hans-Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281573/
https://ncbi.nlm.nih.gov/pubmed/30518958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36330-2
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