Neuronal prostaglandin E(2) receptor subtype EP3 mediates antinociception during inflammation

The pain mediator prostaglandin E(2) (PGE(2)) sensitizes nociceptive pathways through EP2 and EP4 receptors, which are coupled to G(s) proteins and increase cAMP. However, PGE(2) also activates EP3 receptors, and the major signaling pathway of the EP3 receptor splice variants uses inhibition of cAMP...

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Detalhes bibliográficos
Main Authors: Natura, Gabriel, Bär, Karl-Jürgen, Eitner, Annett, Boettger, Michael K., Richter, Frank, Hensellek, Susanne, Ebersberger, Andrea, Leuchtweis, Johannes, Maruyama, Takayuki, Hofmann, Gunther Olaf, Halbhuber, Karl-Jürgen, Schaible, Hans-Georg
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746931/
https://ncbi.nlm.nih.gov/pubmed/23904482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300820110
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