Neuronal prostaglandin E(2) receptor subtype EP3 mediates antinociception during inflammation

The pain mediator prostaglandin E(2) (PGE(2)) sensitizes nociceptive pathways through EP2 and EP4 receptors, which are coupled to G(s) proteins and increase cAMP. However, PGE(2) also activates EP3 receptors, and the major signaling pathway of the EP3 receptor splice variants uses inhibition of cAMP...

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Dades bibliogràfiques
Autors principals: Natura, Gabriel, Bär, Karl-Jürgen, Eitner, Annett, Boettger, Michael K., Richter, Frank, Hensellek, Susanne, Ebersberger, Andrea, Leuchtweis, Johannes, Maruyama, Takayuki, Hofmann, Gunther Olaf, Halbhuber, Karl-Jürgen, Schaible, Hans-Georg
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746931/
https://ncbi.nlm.nih.gov/pubmed/23904482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300820110
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