Insight into mechanisms of 3′-5′ exonuclease activity and removal of bulky 8,5′-cyclopurine adducts by apurinic/apyrimidinic endonucleases

8,5′-cyclo-2'-deoxyadenosine (cdA) and 8,5′-cyclo-2'-deoxyguanosine generated in DNA by both endogenous oxidative stress and ionizing radiation are helix-distorting lesions and strong blocks for DNA replication and transcription. In duplex DNA, these lesions are repaired in the nucleotide...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Mazouzi, Abdelghani, Vigouroux, Armelle, Aikeshev, Bulat, Brooks, Philip J., Saparbaev, Murat K., Morera, Solange, Ishchenko, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746914/
https://ncbi.nlm.nih.gov/pubmed/23898172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305281110
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares